Email : zhou@sinobiochemistry.com Phone : +86-13941198570
 |
| Quantity: | |
|---|---|
PHMB 27083-27-8
SINOBIO
29209090
Poly(hexamethylenebiguanide) hydrochloride (PHMB, CAS No. 32289-58-0) is a polycationic antimicrobial and disinfectant with broad-spectrum antimicrobial activity, chemical stability, and low toxicity. It is widely used in medical, industrial, and consumer applications. However, potential health risks and appropriate usage guidelines should be observed. The following is a detailed introduction to PHMB:
PHMB is the hydrochloride salt of polyhexamethylene biguanide, composed of an average of 12-16 biguanide groups connected by hydrophobic hexamethylene segments, forming a cationic polyelectrolyte structure. Its molecular formula is (C8H17N5)n.xClH, and its molecular weight is approximately 213.32 (monomer repeating unit).
*Appearance: White to off-white powder (solid) or clear liquid (20% aqueous solution).
*Solubility: Readily soluble in water, forming a clear solution.
*Stability: Chemically stable, resistant to high temperatures, acids, and alkalis, and not prone to decomposition under normal storage conditions.
PHMB has a potent antimicrobial effect against bacteria (such as Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA), fungi (such as Candida albicans), molds (such as Aspergillus brasiliensis), and some viruses by disrupting the phospholipid structure of microbial cell membranes and interfering with DNA replication/repair mechanisms. Its antimicrobial spectrum covers Gram-positive and Gram-negative bacteria, as well as drug-resistant strains.
*Acute Toxicity: LD50 (rat oral) >2000 mg/kg, making it a low-toxic substance.
*Irritation: Low irritation to skin and mucous membranes, suitable for wound care and treatment of eye infections.
*Environmental Compatibility: Biodegradable, with low toxicity to aquatic organisms.
PHMB maintains its antimicrobial activity in the presence of hard water, organic matter, and high temperatures, overcoming the vulnerability of traditional disinfectants (such as chlorine) to environmental factors.
| Item | Specification |
| Appearance | Colorless to yellowish clear liquid |
| Relative density | 1.039-1.046 |
| pH | 4.0-5.0 |
| Color (Alpha) | 50max. |
| Absorbance (236nm) | 400min. |
| Assay Polyhexamethylene biguanidine hydrochloride (C8H18ClN5) | 19-21% |
* Wound Care: For antimicrobial treatment of chronic wounds, burns, and wounds at risk of infection, promoting healing and reducing hospital stays.
* Ophthalmic Infections: For the treatment of difficult-to-treat eye infections such as Acanthamoeba keratitis.
* Medical Device Disinfection: As a disinfectant for high-contact instruments such as endoscopes and catheters.
* Water Treatment: As an alternative to chlorine for disinfection of swimming pools, hot springs, and industrial circulating water, reducing the formation of harmful byproducts such as chloramines.
* Textiles and Leather: As an antimicrobial finish, imparting long-lasting antimicrobial properties to fabrics.
* Personal Care: Used in contact lens solutions, wipes, and skincare products to inhibit microbial growth.
* Gene Delivery: Utilizes its cationic properties to carry nucleic acids into cells.
* CO₂ Capture: Used as a functional material to absorb carbon dioxide from industrial waste gases.
* Uranium Recovery: Selectively extracting uranium from nuclear waste.
Poly(hexamethylenebiguanide) hydrochloride (PHMB, CAS No. 32289-58-0) is a polycationic antimicrobial and disinfectant with broad-spectrum antimicrobial activity, chemical stability, and low toxicity. It is widely used in medical, industrial, and consumer applications. However, potential health risks and appropriate usage guidelines should be observed. The following is a detailed introduction to PHMB:
PHMB is the hydrochloride salt of polyhexamethylene biguanide, composed of an average of 12-16 biguanide groups connected by hydrophobic hexamethylene segments, forming a cationic polyelectrolyte structure. Its molecular formula is (C8H17N5)n.xClH, and its molecular weight is approximately 213.32 (monomer repeating unit).
*Appearance: White to off-white powder (solid) or clear liquid (20% aqueous solution).
*Solubility: Readily soluble in water, forming a clear solution.
*Stability: Chemically stable, resistant to high temperatures, acids, and alkalis, and not prone to decomposition under normal storage conditions.
PHMB has a potent antimicrobial effect against bacteria (such as Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA), fungi (such as Candida albicans), molds (such as Aspergillus brasiliensis), and some viruses by disrupting the phospholipid structure of microbial cell membranes and interfering with DNA replication/repair mechanisms. Its antimicrobial spectrum covers Gram-positive and Gram-negative bacteria, as well as drug-resistant strains.
*Acute Toxicity: LD50 (rat oral) >2000 mg/kg, making it a low-toxic substance.
*Irritation: Low irritation to skin and mucous membranes, suitable for wound care and treatment of eye infections.
*Environmental Compatibility: Biodegradable, with low toxicity to aquatic organisms.
PHMB maintains its antimicrobial activity in the presence of hard water, organic matter, and high temperatures, overcoming the vulnerability of traditional disinfectants (such as chlorine) to environmental factors.
| Item | Specification |
| Appearance | Colorless to yellowish clear liquid |
| Relative density | 1.039-1.046 |
| pH | 4.0-5.0 |
| Color (Alpha) | 50max. |
| Absorbance (236nm) | 400min. |
| Assay Polyhexamethylene biguanidine hydrochloride (C8H18ClN5) | 19-21% |
* Wound Care: For antimicrobial treatment of chronic wounds, burns, and wounds at risk of infection, promoting healing and reducing hospital stays.
* Ophthalmic Infections: For the treatment of difficult-to-treat eye infections such as Acanthamoeba keratitis.
* Medical Device Disinfection: As a disinfectant for high-contact instruments such as endoscopes and catheters.
* Water Treatment: As an alternative to chlorine for disinfection of swimming pools, hot springs, and industrial circulating water, reducing the formation of harmful byproducts such as chloramines.
* Textiles and Leather: As an antimicrobial finish, imparting long-lasting antimicrobial properties to fabrics.
* Personal Care: Used in contact lens solutions, wipes, and skincare products to inhibit microbial growth.
* Gene Delivery: Utilizes its cationic properties to carry nucleic acids into cells.
* CO₂ Capture: Used as a functional material to absorb carbon dioxide from industrial waste gases.
* Uranium Recovery: Selectively extracting uranium from nuclear waste.
