What is 8-Hydroxyquinoline?

8-Hydroxyquinoline (8HQ),a quinoline derivative originating in plants as well as from synthesis, has been used as a fungicide in agriculture and a preservative in the textile, wood, and paper industries. 8-Hydroxyquinoline (8-HQ) possesses potent coordinating ability and good metal recognition properties, which means it is widely used for analytical and separation purposes as well as for metal chelation.

Metal ions play a very important role in biological processes, and metal homeostasis is required for the maintenance of metal balance. Many diseases arise from the loss of homeostasis including metal overload and deficiency, which are caused by abnormal metal metabolism or metal absorption. Of all the hydroxyquinoline derivatives, 8-Hydroxyquinoline (8-HQ) is the most interesting one to be explored, owing to its multifunctional properties, such as diverse bioactivities and therapeutic potentials.

8-Hydroxyquinoline (8-HQ) is the only one, among seven isomeric monohydroxyquinolines, capable of forming complexes with divalent metal ions through chelation. Most bioactivities of 8-Hydroxyquinoline (8-HQ) and its derivatives originate from their chelating ability. As previously mentioned, metal imbalance is the leading cause for many diseases, therefore, 8-Hydroxyquinoline (8-HQ) is a potent chelator that may restore metal balance and be useful for the treatment of metal-related diseases.

8-Hydroxyquinoline (8-HQ) is used as an antiseptic and disinfectant. Its alcoholic solution is used in liquid bandages. It is used to prepare tris(8-hydroxyquinolinato)aluminum, which finds application as a component of organic light-emitting diodes (OLED′s). It is also used as a reagent and as a stabilizer of hydrogen peroxide in a rocket fuel oxidizer. It is used as a chelating agent and used as a carrier for radio-indium for diagnostic purposes. Its halogenated derivatives are used as anti-infective agents and oral antiamebics.

SINOBIO focus on the 8-Hydroxyquinoline (8-HQ) for more than 20 years. Recently we export a full container (packed by drum) to the Customer in Columbia.  If any interest, pls feel free to contact us.