Email : zhou@sinobiochemistry.com Phone : +86-13941198570
 |
| Quantity: | |
|---|---|
Ivermectin(IVM)
SINOBIO
29322090
Ivermectin Powder (CAS 70288-86-7) Basic Information and Analysis
Molecular Formula: C₄₈H₇₄O₁₄
Molecular Weight: 875.09 g/mol
Structural Type: Macrolide compound, chemically modified from avermectin, containing 80% 22,23-dihydroavermectin B1a and 20% 22,23-dihydroavermectin B1b.
Appearance: White to slightly yellow crystalline powder, odorless.
Solubility:
Very soluble in methyl ethyl ketone, propylene glycol, and polypropylene glycol;
Slightly soluble in methanol and ethanol;
Almost insoluble in water (solubility in water approximately 4 μg/mL).
Melting Point: 155–157°C (crystallization in ethanol-water).
Stability: Stable in solid form for 2 years. DMSO or ethanol solutions are stable for 3 months at -20°C.
Storage Conditions: 2–8°C (reagent grade), room temperature (industrial grade), sealed and protected from light.
Ivermectin (IVM) represents a groundbreaking class of highly effective, semi-synthetic antibiotics specifically engineered to combat a broad spectrum of pests, including insects, mites, and nematodes. It falls under the category of neurotoxic insecticides and biological penetrants, leveraging advanced chemical mechanisms to disrupt the physiological processes of target organisms. As a novel, broad-spectrum antiparasitic agent, Ivermectin exhibits remarkable efficacy with low toxicity, making it a preferred choice for managing both internal and external parasitic infestations. Its potency is particularly pronounced against nematodes (roundworms) and arthropods (such as mites and ticks), while it remains ineffective against tapeworms, flukes (trematodes), and protozoan parasites.
The mode of action underlying Ivermectin's antiparasitic effects is rooted in its ability to interfere with the nervous system of susceptible organisms. Specifically, it enhances the release of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter in parasites, by acting on presynaptic neurons. This surge in GABA levels leads to the hyperpolarization of postsynaptic membranes through the activation of GABA-gated chloride channels. Additionally, Ivermectin potentiates the opening of glutamate-gated chloride channels, further amplifying chloride ion influx into nerve cells. The cumulative effect of these actions is a dramatic increase in the permeability of the nerve membrane to chloride ions, resulting in a sustained hyperpolarized state.
| Product Name | Ivermectin | |
| Cas No.: | 70288-86-7 | |
| EINECS No | 274-536-0 | |
| Reference | USP | |
| Test Item | Specification.EP | Test results |
| Appearance | White or yellowish-white crystalline powder | White-crystalline powder |
| Appearance of solution | The solution is clear and not more intensely Coloured than reference solution BY7 | Clear |
| Identification IR HPLC | Corresponds with that of CRS standard The retention time for H2B1a and H2B1b Corresponds to CRS | Complies |
| Water | Not more than 1.0% | 0.15 |
| Ethanol | Not more than 5.0% | 3.3 |
| Formamide | Not more than 3.0% | 2.0 |
| Ratio H2B1a /(H2B1a+ H2B1b),a | Not less than 90.0% | 95.2 |
| Assay(H2B1a+ H2B1b) (anhydrous and solvent-free substance) | 95.0%~102..0% Between95.0% and 102.0% | 97.5 |
| Related compounds | 1:Theindividual impurity(RRT1.3-1.5),Not more than 2.5% 2:Any other individual impurity not more than 1% 3:Sum of total impurities not more than 5% 4:Disregard peaks less than 0.05% | 1:1.50 2:0.50 3:2.1 4:0.05 |
| Heavy metals | Not more than 20ppm | <20ppm |
| Sulphated ash | Not more than 0.1% | <0.07 |
| Specific optical rotation(anhydrous and solvent-free substance) | Between-17o--20o | -19o |
| Residual solvents | Not more than 890ppm | <890ppm |
| Conclusion | Complies with the requirement of USP | |
*Targets: Nematodes, arthropods (e.g., mites, insects).
*Mechanism of Action:
- Promotes the release of gamma-aminobutyric acid (GABA) from presynaptic neurons, opening GABA-mediated chloride channels;
- Increases the permeability of nerve membranes to Cl⁻, blocking neural signal transmission, leading to paralysis and death of parasites.
*Spectral Range:
- Effectively kills gastrointestinal nematodes, lungworms, and external parasites (e.g., mites and lice);
- Ineffective against tapeworms, flukes, and protozoa.
*Antirirality: In vitro studies have shown inhibitory effects against HIV-1, SARS-CoV-2, and dengue virus.
*Neuromodulation: Acts as a positive allosteric modulator of the α7 nicotinic acetylcholine receptor, modulating glutamate-GABA-activated chloride channels.
*Animal Species: Cattle, sheep, horses, pigs, dogs, poultry.
*Indications:
-Gastrointestinal nematodes and lungworms;
-External parasites (e.g., scabies, ear mites, heartworm microfilariae);
-Bovine myiasis and myiasis.
*Dosage Forms: Injection, tablet, feed additive.
*Applications: Agricultural insecticide and acaricide.
*Target Pests: Plant mites, diamondback moth, cabbage worm, leaf miner, psyllid, and nematodes.
Packing: 1kg / aluminum foil bag, 25kg /drum. We provide customized package for different quantity.
Shipping: by express DHL,FEDEX,TNT......or as your requirement.
Payment: T/T,western union,moneygram or as your requirement.
Ivermectin Powder (CAS 70288-86-7) Basic Information and Analysis
Molecular Formula: C₄₈H₇₄O₁₄
Molecular Weight: 875.09 g/mol
Structural Type: Macrolide compound, chemically modified from avermectin, containing 80% 22,23-dihydroavermectin B1a and 20% 22,23-dihydroavermectin B1b.
Appearance: White to slightly yellow crystalline powder, odorless.
Solubility:
Very soluble in methyl ethyl ketone, propylene glycol, and polypropylene glycol;
Slightly soluble in methanol and ethanol;
Almost insoluble in water (solubility in water approximately 4 μg/mL).
Melting Point: 155–157°C (crystallization in ethanol-water).
Stability: Stable in solid form for 2 years. DMSO or ethanol solutions are stable for 3 months at -20°C.
Storage Conditions: 2–8°C (reagent grade), room temperature (industrial grade), sealed and protected from light.
Ivermectin (IVM) represents a groundbreaking class of highly effective, semi-synthetic antibiotics specifically engineered to combat a broad spectrum of pests, including insects, mites, and nematodes. It falls under the category of neurotoxic insecticides and biological penetrants, leveraging advanced chemical mechanisms to disrupt the physiological processes of target organisms. As a novel, broad-spectrum antiparasitic agent, Ivermectin exhibits remarkable efficacy with low toxicity, making it a preferred choice for managing both internal and external parasitic infestations. Its potency is particularly pronounced against nematodes (roundworms) and arthropods (such as mites and ticks), while it remains ineffective against tapeworms, flukes (trematodes), and protozoan parasites.
The mode of action underlying Ivermectin's antiparasitic effects is rooted in its ability to interfere with the nervous system of susceptible organisms. Specifically, it enhances the release of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter in parasites, by acting on presynaptic neurons. This surge in GABA levels leads to the hyperpolarization of postsynaptic membranes through the activation of GABA-gated chloride channels. Additionally, Ivermectin potentiates the opening of glutamate-gated chloride channels, further amplifying chloride ion influx into nerve cells. The cumulative effect of these actions is a dramatic increase in the permeability of the nerve membrane to chloride ions, resulting in a sustained hyperpolarized state.
| Product Name | Ivermectin | |
| Cas No.: | 70288-86-7 | |
| EINECS No | 274-536-0 | |
| Reference | USP | |
| Test Item | Specification.EP | Test results |
| Appearance | White or yellowish-white crystalline powder | White-crystalline powder |
| Appearance of solution | The solution is clear and not more intensely Coloured than reference solution BY7 | Clear |
| Identification IR HPLC | Corresponds with that of CRS standard The retention time for H2B1a and H2B1b Corresponds to CRS | Complies |
| Water | Not more than 1.0% | 0.15 |
| Ethanol | Not more than 5.0% | 3.3 |
| Formamide | Not more than 3.0% | 2.0 |
| Ratio H2B1a /(H2B1a+ H2B1b),a | Not less than 90.0% | 95.2 |
| Assay(H2B1a+ H2B1b) (anhydrous and solvent-free substance) | 95.0%~102..0% Between95.0% and 102.0% | 97.5 |
| Related compounds | 1:Theindividual impurity(RRT1.3-1.5),Not more than 2.5% 2:Any other individual impurity not more than 1% 3:Sum of total impurities not more than 5% 4:Disregard peaks less than 0.05% | 1:1.50 2:0.50 3:2.1 4:0.05 |
| Heavy metals | Not more than 20ppm | <20ppm |
| Sulphated ash | Not more than 0.1% | <0.07 |
| Specific optical rotation(anhydrous and solvent-free substance) | Between-17o--20o | -19o |
| Residual solvents | Not more than 890ppm | <890ppm |
| Conclusion | Complies with the requirement of USP | |
*Targets: Nematodes, arthropods (e.g., mites, insects).
*Mechanism of Action:
- Promotes the release of gamma-aminobutyric acid (GABA) from presynaptic neurons, opening GABA-mediated chloride channels;
- Increases the permeability of nerve membranes to Cl⁻, blocking neural signal transmission, leading to paralysis and death of parasites.
*Spectral Range:
- Effectively kills gastrointestinal nematodes, lungworms, and external parasites (e.g., mites and lice);
- Ineffective against tapeworms, flukes, and protozoa.
*Antirirality: In vitro studies have shown inhibitory effects against HIV-1, SARS-CoV-2, and dengue virus.
*Neuromodulation: Acts as a positive allosteric modulator of the α7 nicotinic acetylcholine receptor, modulating glutamate-GABA-activated chloride channels.
*Animal Species: Cattle, sheep, horses, pigs, dogs, poultry.
*Indications:
-Gastrointestinal nematodes and lungworms;
-External parasites (e.g., scabies, ear mites, heartworm microfilariae);
-Bovine myiasis and myiasis.
*Dosage Forms: Injection, tablet, feed additive.
*Applications: Agricultural insecticide and acaricide.
*Target Pests: Plant mites, diamondback moth, cabbage worm, leaf miner, psyllid, and nematodes.
Packing: 1kg / aluminum foil bag, 25kg /drum. We provide customized package for different quantity.
Shipping: by express DHL,FEDEX,TNT......or as your requirement.
Payment: T/T,western union,moneygram or as your requirement.
